Since the eighties of last century, the single individual project is gradually taken place by programs. The program management challenges the traditional methods and technologies for management as programs are much more complex than the single individual projects. In order to improve the program management performance, the essay comes up with the adoption of the new information technology cloud computing in program management. Based on the example of Shanghai 2010 Expo, we come to the conclusion that the application of cloud computing can highly improve the performance of program management with its powerful capacity.