In recent years, there have been concerns raised about prefabricated building in China, which have initiated a wave of policy change in both governmental and industrial organizations in order to change the mode of conventional construction. However, the prefabricated building supply chain (PBSC) is more complex than other manufacturing industry. This study took the information flow as the breakthrough point, analyzed the whole life cycle information flow of the prefabricated building. In addition, building information model (BIM) was then employed to construct the integrated model of PBSC. Finally, the model structure and content were presented. These findings provide an effective approach to improve the efficiency and benefit of PBSC.